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Pretreatment of the extract (150 mg/kg) could significantly decrease the mortality by reducing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when applied APAP at a dose of 1 g/kg, which was a 100% lethal dose in the experiment

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Sex as a biological variable: we utilized only male rats to maximize the satellite cell yield per gram of muscle tissue and individual animal (Figure 1d,f and supplementary Figure 1a) and male mice to examine the preventive effect of oral administration of glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS) (Figure 2e) on disuse-induced nitration-dysfunction of ECM-bound HGF

These findings suggest that suppression of the JAK2/STAT3 axis is a key mechanism by which EC attenuates inflammatory responses in macrophages (Yang et al., 2015)

We would like to thank Research Councils UK for funding GT and acknowledge the support from West Midlands Advantage for some equipment funding and thank George Eliot Hospital Diabetes research fund, Nuneaton, UK and Warwick-QMUL collaboration award for funding for this research